Carbopol 934 properties. 91-22-6663 6663 info@lobachemie.

Carbopol 934 properties CARBOPOL(TM) 934 - Use. This stability is expected due to Carbopol 934’s properties, facilitating dispersion in the water despite its low concentration. Attention! Your ePaper is waiting for publication! By publishing your document, the content will be optimally indexed by Google via AI and sorted into the right category for over 500 million ePaper readers on YUMPU. 80 CPs at 10 RPM. S. Carbopol 940, 941, and 934 were breakthrough technologies that revolutionized how personal care products are formulated and created new types of products that were previously not possible to make. Li> is used to prepare leather and some high-grade products, acrylic resin paint, etc. It has short flow property and offers excellent thickening for opaque gels, creams, lotions and suspensions. 17 *HPMC K4M + 22. Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. -- (9003-01-4) ATOMIC OR MOLECULAR FORMULA -- ATOMIC OR MOLECULAR WEIGHT -- PROPERTIES -- PARAMETER LIMIT Description White to off white powder. The rheological properties of Carbopol dispersions in water and in water/glycerol solutions were investigated for concentrations ranging from 0. 1. [19]. Therefore, it was concluded that AG when combined with a mucoadhesive agent like CP have much improved potential to effectively deliver drugs. 555688 (2022) 001 Formulation and In-vitro Characterization of Aceclofenac Emulgel Prepared using Carbopol 934 and Sodium CMC Bipindra Pandey1ϯ, Laxman Subedi1, 2ϯ and Rishiram Baral1, 3* 1School of Health and Allied Sciences, Faculty of Health Science, Pokhara University, Nepal 2Department of Biomedicine, This study recommends Carbopol/zinc oxide (ZnO) hybrid nanoparticles gel as an efficient antibacterial agent against different bacterial species. (See Figure 9. preparations were evaluated for physical properties, namely organoleptic, homogeneity, adhesion, pH, dispersibility, and viscosity. Colloids Surf B Biointerfaces. Application. (2013) reported carbopol 934 based bioadhesive topical gel of 5-Fluorouracil with properties compared to the commercially available creams [23]. · In this study triethanolamine and sodium ca~. ) Effects of Carbopol® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: A skin permeation study. patches formulation carbopol 934 properties. , Ahmedabad, India). Carbopol 934 is suspending agent which have been studied to produce a stable suspension. To start, a Carbopol stock Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application It is an ideal property of penetration enhancers to abridge reversibly the barrier property of the stratum corneum without causing any harm to viable cells (Barry 1983, Williams and Barry 2012). Because of its properties, carbopol has the potential to be useful as a pharmaceutical In-vitro residence time = +150. ThermoFisher: Carbopol 940 SDS; Physical and Chemical Properties. This interaction phenomenon is clearly shown in the FTIR spectra shift of the carbonyl stretch of carbopol. 4 were used as neutralizing agents to assess their effects on the gel-forming and swelling properties of Carbopol ® 940. To prevent complete dissolution in water, a neutralizing agent like TEA (triethanolamine) is essential. Bhakti Todmal, Anjali Pande, Rachna Vidhate, Gaurav Jedhe, Omkar Zalte, " Formulation And Evaluation of Diclofenac Sodium Gel By Using Carbopol 934, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 10, Issue 6, pp. Craig Topical gel formulations of Aceclofenac were prepared using these polymers such as Carbopol-934, Carbopol-940, HPMC, Poloxamer 407 in different concentration for the treatment of rheumatoid arthritis. (1975) S. Solubility When neutralised with alkali hydroxide or amine it dissolves in Applicable synonyms for Carbopol ® 934 NF polymer: Carbomer, carboxypolymethylene. 0 - 6. 9007-16-3(Carbomer934) Product Description. The test results were analyzed with DX 12 to get the optimum formula. Molecular Formula: C5H10O2: Molar Mass: 102. Their innovative technologies modify physical properties, enhance functional performance and ease of use and deliver aesthetic benefits to support key Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. Similarly, drug delivery strategies have been explored to obtain solids with better wetting and dissolution properties of TCZ, aiming to enhance their bioavailability and enhance the therapeutic In conclusion, buccal patches consisting of a homogeneous mixture of polyisobutylene, polyisoprene, and Carbopol® 934P formed by a two-roll milling process appear to possess physical properties Compared with other gelling agents such as Carbopol 934 and Ultrez 10, Carbopol 940 was found to have superior flow-modifying properties for topical delivery and a greater effect in extending drug Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. s. 1317: Density: 1. [4,5] It consists of chains of polyacrylic acid having cross linking agent, allyl ethers of sucrose (allylsucrose) [Figure 2]. 0; pH of 1% dispersion is about 2. This result was unexpected as it was anticipated that both these rheological properties of the carbopol dispersions would 3000 5000 Shear stress ( OYN cm-2 ) Research Article. Relevant identified uses The Physicochemical properties, characterization including stability studies of the prepared nanoparticles were carried out using pharmacopeial techniques of zeta potential, Carbopol-934 was dispersed in distilled water slowly to form solution A, which was mixed well and placed on a magnetic stirrer. It is used after neutralisation and its rheological properties in the aqueous medium are well known. Each formula was packed Carbopol 934P (934P) is highly cross-linked with excellent stability at high viscosities, which confers excellent bioadhesive and viscoelastic properties. Carbopol® polymers are available as fluffy white powders, which are able to absorb large Glass transitions of five varieties of Carbopol ® (acrylic acid polymers cross-linked with allyl sucrose or allyl pentaerythritol) and two varieties of Noveon ® (calcium salts of acrylic acid polymer cross-linked with divinylglycol) differing in cross-linking density and nature and content in residual solvents, were analysed (as compressed probes) by differential scanning Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. Triethanolamine . 2 Department of Biomedicine, Health & Life Convergence Sciences, This research was carried out to create a pH-responsive polymeric system for the targeted drug delivery of Diloxanide furoate. Carbopol® polymers, Pemulen™ polymeric emulsifiers and Noveon® polycarbohil are high molecular weight, cross-linked homopolymers and copolymers of acrylic acid. Carbopol 934 is a hydrophilic polyacrylic acid polymer, and after neutralisation, its carboxyl groups become highly ionised, forming a gel due flow properties in topical, lotions, creams, and gels, oral suspensions, and transdermal gel reservoirs. [20] Carbopol 940 has excellent cross-linking and swelling properties. Appearance (Form) Powder. General properties. The mean viscosity values were recorded as 205 cP (HPMC), 220 cP (Carbopol 940), and 231 cP (Carbopol 934). The patches were evaluated for their thickness, weight and content uniformity, swelling behavior, drug–polymers interaction, adhesive properties, and drug release. The polymers are not soluble due to their crosslinked nature and high molecular weight. The model drug was theophylline. The levels of these factors were selected on the basis of initial Formulation and Characterization of Carbopol-934 Based Kojic Acid-Loaded Smart Nanocrystals: nanocrystals have a great influence on important properties, such as drug release kinetics, Carbopol is one of the most common thickening agent for water phases. 135%, and chitosan 0,193% had adhesion of Nov Appro Drug Des Dev 6(3): NAPDD. Moreover, phosphate buffer and triethanolamine solutions pH 7. The three-dimensional network structure of the closely packed, swollen microgels Carbopol 934 dan natrium lauril sulfat Met Komposisi dari pembuatan emulgel tabir surya terdiri dari nanopartikel seng oksida, minyak zaitun, natrium lauril sulfat, Carbopol 934, metil paraben, propil paraben, setil alkohol, tokoferol, dan akudes. SisHBirinciMEffect of nonionic and ionic surfactants on zeta potential and dispersion properties of carbon black powders Colloids Surf A Physicochem Eng Asp 20093411–36067 gum of superior gel-forming properties, Carbopol 9341 (carboxy polymethylene), has been made available. español. In this study, made 3 formulations CARBOPOL(R) 934 Request for Quotation POLY(ACRYLIC ACID) CAS: 9007-16-3 Molecular Formula: C5H10O2. 50 ml . Nov Appro Drug Des Dev 6(3): NAPDD. en. this product is a light yellow liquid. 1% v/v . Personal care. 75 mg to 300 mg of Carbopol 934 for buccal . The optimum formula based on factorial design method was FormulaA (Carbopol 934 and PGA low concentration) with value of desirability 0,684 and showlow viscosity, particles rapidly settle but easy redispersibility. METHODS PREPARATION OF GEL : Carbopol 934 gels were meticulously crafted through a well-orchestrated process. ~OO N eocalamine 15 Glycerin 4 0. Analytical statistic ofphysical properties in optimum formula and prediction show insignificance difference (pvalue> 0,05). A single particle of Carbopol® will wet out very rapidly when put in water. from publication: Formulation and Characterization of Febuxostat Loaded Nanostructured Lipid HPMC K4M, Carbopol 934, sodium CMC, sodium bicarbonate, talc, lactose, and magnesium stearate were selected as the other components. 1 to 0. Oxidizing properties: No data available. The broad- Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. Moreover, Nicotine patches were prepared using xanthan gum or carbopol 934 as a mucoadhesive polymers and ethyl cellulose as a backing layer. Stokes and Telford [24] showed some data obtained with Carbopol 934 and a smooth vane in a large container, which compare with more detailed data obtained by Uhlherr et al. 12 to 3518. In making up gels from Carbopol 934, the Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. This product is suggested for use in lotions and creams. 5% m/v carbopol-934 is considered the promising formula which showed better physicochemical properties and exhibited good anti-microbial activity against both Carbopol 934-Sodium Alginate-Gelatin Mucoadhesive Ondansetron Tablets for Buccal Delivery: In addition to the above properties prepared tablets, formulations were also evaluated for microenvironmental pH, in vitro release, bioadhesion, water uptake and in vitro permeation. Categories. 1016/0168-3659(94)90027-2 Corpus ID: 94078493; An investigation into the structure and properties of Carbopol 934 gels using dielectric spectroscopy and oscillatory rheometry Product name : Carbopol 934 Cas No. 8 to 7. 2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Oxidising properties : No data available Explosive limits : No data available 9. The optimum concentration of carbopol®934 was 0,878%, HPMC 1. 20-100%. Davis Viscoelastic properties of pharmaceutical semi-solids. Chemical Name: CARBOMER/ CARBOPOL 934, 940, 941 Synonyms CARBOMER/ CARBOPOL 934, 940, 941 CBNumber: CB31091338 Molecular Formula: Molecular Weight: CARBOPOL(TM) 934 - Chemical properties. Carbopol-934 (C), gelatin (G), sodium alginate (SA), magnesium stearate, microcrystalline cellulose (Loba Chemie Laboratory The diffusion properties of methotrexate (MTX) in two hydrogels, Carbopol 934 (Carbopol) and Poloxamer 407 (PF-127), were compared with those in PEG 1500 and white petrolatum ointments in order to evaluate various factors governing the diffusion of MTX in different semisolid vehicles. M. emulsion prior to neutralizing the Carbopol® to build emulsion viscosity. carbomer; carboxypolymethylene Risks. FEBS Lett. 1 %. Various batches of GLP beads were prepared by an emulsion-solvent evaporation technique using the release-retarding polymer carbopol and SDS_REG_GHS - CARBOPOL® 934 NF POLYMER 5/10 Autoignition Temperature: Approximate 480 °C Decomposition Temperature: No data available. 40±0. 25,26 (A) (B) Request PDF | Poly(acrylic acid) microgels (carbopol (R) 934)/surfactant interactions in aqueous media Part II: Ionic surfactants | The interaction of sodium dodecylsulfate (SDS) or benzalkonium This research was carried out to create a pH-responsive polymeric system for the targeted drug delivery of Diloxanide furoate. 52 ± The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol ® 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of DOI: 10. from publication: Formulation and Characterization of Febuxostat Loaded Nanostructured Lipid Carriers (NLCs More than 90% of drug entrapment was reported for optimized formulation with excellent mucoadhesive property with biological membrane. developed a honey-based hydrogel using chitosan, carbopol 934 and different concentration (25%, 50%, and 75%) Although the general conclusion drawn in Barry and Meyer [6] is that the rheological properties of Carbopol® gels are practically insensitive to temperature variations Thus, various studies used various grades of Carbopol (934, 940, Ultrez 10 etc. Rheological monitoring Usually, the release rate of a drug from a semi-solid matrix is inversely proportional to its solid character but previous studies (Lochhead et al. Note: Dispersions of Carbopol® polymers made to a precise solids level for analytical . Tackifier, emulsion and suspension stabilizer. Using a glass rod, the final translucent formula was simply mixed to create a homogeneous mixture. ) Boling Point: 116 Effects of Carbopol ® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study. MATERIALS AND METHODS Ondansetron HCl was received as a generous gift from commercial suppliers (Ellis Pharma Pvt. Pharm TDS-730 Viscosity of Carbopol® Polymers in Aqueous Systems Page 2 of 10 Table 1B: Compendial Status of Polymers Product Trade Name United States USP/NF* Europe (Ph. Carbomers are a group of closely related synthetic, high molecular weight, Carbomers (Carbopol 940, 941, and 934) revolutionised topical products by enabling formulators to create new types of products previously not possible. Upon neutralization with sodium hydroxide a highly viscous gel is formed, even at a concentration of only 0. 1%. The use of lower polymeric content offers minimal buffering capacity and lower thermal gelation threshold which results in rapid sol-gel Download scientific diagram | Properties of Gel formulation containing Carbopol -934. Enable highly effective controlled-release properties for oral tablets, critical rheological and bioadhesive properties for topical formulations, and patient-centric benefits across multiple dosage forms. 0. CAS No. The effect of pH on the swelling of polyacrylic acid polymers was studied at constant temperature, ionic strength Present study demonstrates carbopol-934, sodium alginate, gelatin polymer system with added pH modifier can be successfully formulated for buccal delivery of ondansetron with desired release profile. The coded equation is useful for identifying the relative impact of the factors by comparing the factor coefficients. com. Puri et al. Carbopol 934 NF polymer: Carbopol 5984 EP and Ultrez 10 NF polymers: Carbopol 934P NF polymer: Carbopol 974P NF polymer: Carbopol 940 NF Download Citation | Pharmaceutical Uses of Carbopol® 934* The complexing properties of carboxymethylcellulose sorbent CM-52 towards ions of Cu 2+, Co 2+, Ni 2+, Cd 2+, Compared with other gelling agents such as Carbopol 934 and Ultrez 10, Carbopol 940 was found to have superior flow-modifying properties for topical delivery and a greater effect in extending drug Due to its synthetic nature, physical and chemical properties of Carbopol® can be fine-tuned to make it suitable for various biomedical applications. The name Carbopol® identifies a family of polymers based on modified cross-linked acrylic acid chemistry. Carbopol-934 was dispersed in distilled water slowly to form solution A, which was mixed well and placed on a magnetic stirrer. Pada formulasi ini dilakukan optimasi konsentrasi Carbopol 934 dan natrium lauril sulfat Three Carbopol ® resins: 934, 940 and Ultrez 10, were utilized in various concentrations to achieve these goals. Lubrizol’s benzene polymerized polymers do not meet the European Pharmacopeial “Carbomers” monograph because the residual benzene levels exceed the 2 ppm limit The 1% Carbopol-934 formulated gel was found highest drug content (101. Craig Duncan Q. 22 The physicochemical properties observed were pH to be 6. November 2016; International Journal of Nanomedicine Volume 11:5971-5987; Carbopol;CARBOPOL 941;CARBOPOL 934;Carbopol 980;KBM;POLYACRYLIC ACID 5,000;Carbome;carbopol U21;CARBOMER 941;CARBOMER 1622 CBNumber: CB9693151 These properties - acid-base and water-attracting - are the bases of many applications. 31 ± 1. 165-177. permeation, drug release and formulation properties. Home; About Us; Markets. It exhibits short flow (quick recovery) properties in aqueous systems. Starting in the 1980s new products and processes using ethyl acetate and ethyl acetate/cyclohexane cosolvents EFFET OF COMBINATION OF HPMC AND CARBOPOL 934P ON THE PROPERTIES OF THE GASTRIC FOATING TABETS TIMOLOL MALATE Charyulu Narayana R*, Girish S K, Amit B Patil. (9003-01-4) ATOMIC OR MOLECULAR Small strain testing investigated fundamental properties of Carbopol gels and determined the effect of polymer concentration, temperature, neutralization, different solvents The present study aimed to formulate and evaluate topical hydroxypropyl methylcellulose (HPMC)/carbopol 934 gels for wound healing purposes. Positive outcomes were seen in the Carbopol 934 . 1 School of Health and Allied Sciences, Faculty of Health Science, Pokhara University, Nepal. It exhibits short flow properties and a creamy sensory profile, and is therefore well suited for use as a rheology Where lot test frequency is less than 1:1, Lubrizol Advanced Materials, Inc. Other information Bulk density: < 0,24 g/ml (25 °C) to optimize the concentration of Carbopol 934 and HPMC E15. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910. Positive outcomes were seen in the delivery, a carbopol gel was made. Stability studies showed that the physical appearance, rheological properties and drug release remained unchanged upon storage for three months at ambient conditions. Neutralization of Carbopol® is accomplished with a suitable alkali or amine base. Pada formulasi ini dilakukan optimasi konsentrasi Carbopol 934 dan natrium lauril sulfat General properties. DOI: 10. It exhibits short flow properties and a creamy sensory profile, and is therefore well suited for use as a rheology Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. The first Carbopol polymers, developed in 1958, used benzene as the polymerization solvent. , 2020; Batool et al. In no case were the Effects of Carbopol® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study Yin Zheng,1 Wu-Qing Ouyang,1 Yun-Peng Wei,1 Shahid Faraz Syed,2,3 Chao-Shuang Hao,1 Bo-Zhen Wang,4 Yan-Hong Shang1,5 1Department of Basic Veterinary Sciences, College of Veterinary Medicine, 2Department of Mucoadhesive polymeric (carbopol 934) suspension of ciprofloxacin was prepared by ultrasonication and optimized with the aim of developing an oral controlled release gastro-retentive dosage form. UNIVERSAL POLYMER ULTREZ 10 Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. 133 or European Standard EN166. Last Update：2024-04-20 12:50:57. 40 ± 0. certifies that each batch/lot meets requirements for the characteristics based on historical process and product data. Besides, it gives a significantly higher yield of drug release than that of carbopol 934 and 980 [23]. Effects of pH and concentration of Carbopol 934 (Shafiei et al. Product identifier Product form : Substance: CAS-No. Subchronic feeding of rats with doses up to 0. The coefficients used in both correlation formulas are related to the intrinsic properties of the Carbopol and solvent, In this study, influence of several physico-chemical properties of bioadhesive polyacrylic acid poylmers (Carbopol 910, Polycarbophil, Carbopol 940 and Carbopol 934 PH) are investigated. With increasing Car- ChemicalBook Provide 9007-16-3(Carbomer934)Melting Point Boiling Point Density,9007-16-3(Carbomer934) CAS Chemical Properties MSDS. prepared from 1% w/v of Carbopol 934(F2) showed excellent extrudability with semisolid consistency and viscosity of 4260±0. Initial formulations (CG1–CG5) were made, and their varied medicinal properties were assessed. The PS and DI of nanocrystals have a great influence on important properties, such as drug release kinetics, drug Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. Carbopol® 934 NF polymer meets the limits cited in the current edition of the following monograph: • United States Pharmacopeia/National Formulary (USP/NF) monograph for It is cross-linked polyacrylic acid polymer. When neutralized with sodium hydroxide to a pH of 7. 0 μm. Carbopol® 934 Polymer offers excellent stability at high viscosity and produces thick formulations such as heavy gels, emulsions and suspensions. 100 A wide variety of alkaline substances may ~be used to neutralize the acidic, polymeric Carbopol 934 in the preparation of the mucilage. 1016/0168-3659(94)90027-2 Corpus ID: 94078493; An investigation into the structure and properties of Carbopol 934 gels using dielectric spectroscopy and oscillatory rheometry Three Carbopol ® resins: 934, 940 and Ultrez 10, were utilized in various concentrations to achieve these goals. /li> A carboxyvinyl-polymer of Goodrich Chemical Co. Skin contact and inhalation of dust may cause irritation. Our organic solvents, meticulously selected for quality, were all of high-grade analytical purity. Its designation “P” refers to the pharmaceutical grade because it has a low residual benzene content [23,27]. 65 *Carbopol 934 &HPMC K4M . : 9003-01-4 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking 1. (Carbopol 934)/surfactant interactions in aqueous medium. Polym ers 2022 , 14 , x FOR PEER REVIEW 7 of 12 S10 Et hocel 1 0 FP + C a rbopol 934 P NF (1 0:5) wi t h HPMC 9 9 . considering Carbopol 934, 2984 or 5984 polymer for a cream or lotion; or Carbopol 940 or 980 polymer for a clear gel, try Carbopol Ultrez 10 instead. A granular carbomer is also available (Carbopol 71G). Blokhus and Klokk, 2000. The effect of a number of variables on the dielectric and rheological behaviour have been studied; these include the presence of a gelling agent (triethanolamine), changing the concentration of polymer, the addition of propylene glycol and Description. An unneutralized 1% dispersion of Carbopol ® 934 NF polymer in water has a viscosity of only 390 cP. The new and published results show that Carbopol®'s rheology is strongly dependent on concentration, composition, pH, temperature, aging and preparation procedure. Carbopol® 934 NF polymer meets the limits cited in the current edition of the following monograph: Japanese Pharmaceutical Excipients (JPE) Monograph for Carboxyvinyl Polymer † General Product Characteristics In this investigation, Carbopol 934 gels have been studied using dielectric spectroscopy and oscillatory rheometry. Pharm. Therefore, the research was done to see whether Carbopol 934 can produce a stable suspension of ibuprofen. Different formulas were prepared Carbopol 934P is a pH-responsive gelling agent. View PDF View article View in Scopus Google Scholar. 2 and viscosity is from 36,000 to 51,000 cps. ) or even custom gel formulations, Owen et al. I Ointment basis. Carbopol: sodium CMC, Carbopol 934, marketed gel and Carbopol: guar gum. It exhibits short flow properties and a creamy hair care, bath &shower, surface, dish and fabric care. Carbopol ® 934 NF Polymer Carbopol 5984 EP and Ultrez 10 NF Polymer Carbopol ® 934P NF Polymer Carbopol 974P NF Polymer Carbopol® 940 NF Polymer Carbopol® 980 NF and Ultrez 10 NF Polymer Carbopol ® 941 NF Polymer Carbopol 71G NF, 971P NF and 981 NF Polymer Carbopol® 1342 NF Polymer Pemulen™ TR-1 NF and TR-2 NF Polymer The rheological properties of Carbopol dispersions in water and in water/glycerol solutions were investigated for concentrations ranging from 0. with a very high molecular weight. 4. 5% Carbopol 934 ~ucilage, q. 5 g . The The present investigation was aimed at exploitation of the mucoadhesive potential of carbopol 934P polymer in developing microbeads of glipizide (GLP) for its effectivity in controlling blood sugar in diabetic patients. , 2021 Carbopol is one of the most common thickening agent for water phases. Carbopol® samples exhibit visco-elasto-plastic properties: shear thinning behavior under an applied strain rate (or shear stress) and a yield stress, over which flow and plastic deformations occur. Carbopol 934P was procured from Genuine Chemicals in the vibrant city of Mumbai, India. Relevant identified uses of the substance or mixture and uses advised against 1. Formulation and In-vitro Characterization of Aceclofenac Emulgel Prepared using Carbopol 934 and Sodium CMC Bipindra Pandey 1ϯ, Laxman Subedi 1, 2ϯ and Rishiram Baral 1, 3 *. mucoadhesive agent for topical application and 2 articles utilised 18. Chemical Properties. It exhibits short flow properties and creamy sensory profile. Polymer science compounds,Polymers. Key Features: Thickener and rheology modifier ; Additional Features: Nanoemulsions were characterized for particle size and zeta potential. 92±1. , 2006). , 1989) have already demonstrated that higher viscosity gels made by Carbopol 974 and Carbopol 934 showed a non-homogeneous viscosity with regions characterised by a very high macroviscosity and regions extract were developed using Carbopol® 934 and were characterized for rheological properties (spreadability, viscosity), drug release and prolong anti-oxidant profile. Chemical Name CARBOPOL 941 CARBOPOL 934 CARBOPOL(R) 934 CARBOPOL(R) 941 CARBOPOL(TM) 910 CARBOPOL(TM) 934. Both anionic and cationic surfactants significantly altered the properties of carbopol microgels solutions. ) Rauschert), a plant used for centuries for its medicinal properties (Sadr Lahijani et al. North seven road, Jinzhai modern industrial park, Anhui +86-18138768519 sales@chinanewman. The study higher yield of drug release than carbopol 934 and 980. I: Nonionic surfactants. 5% Carbopol 934 mucilage, q. (BVEN) was prepared by ionic gelation method, incorporated in carbopol 934 gel. Active substances can affect the physical properties of gel preparations and their stability. Explosive properties: No data available. It shows excellent freeze-thaw and high temperature stability at low Carbomer 934/NM –Carbomer 934 is a cross-linked polyacrylate polymer. e. Safety Information for this product is Carbopol 934 (C934) is a mucoadhesive, biodegradable and environmentally responsive carbopol polymer and is considered as ‘smart gels’. 934, 940, 941 are used as the suffix within the carbomer nomenclature to provide an indication of their molecular weight and specific components of the polymer (Lubrizol, 2005). The amount of Carbopol 934 (X 1, % w/w) and HPMC E15 (X 2, % w/w), were selected as the independent variables i. Author links open overlay panel Yasmeen a, Mohd Ashif class Ⅱ, derived from glycyrrhiza glabra that exhibits anti-viral, anti-inflammatory, neuroprotective, and anti-tumor properties, in addition to its antioxidant activity. ID. 9 Aslani[24] Method: carbopol 940 has acidic properties [6]. pKa = 5. 10-15, November-December-2023. According to preformulation Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. 4 ± 0. Home; Product Category; CARBOPOL(R) 934 ; Home; CAS; CAS 900; CARBOPOL(R) 934 - Physico-chemical Properties. Carbopol gels show viscoelastic properties and help to maintain the texture by thickening There are many polymers like carbopol 934 (Said dos Santos et al. 9007-16-3. higher yield of drug release than carbopol 934 and 980. For the order of neutralizer addition in gel products, see the Carbopol® Troubleshooting Guide. 0, the viscosity increases above 50,000 cP. Three Carbopol ® resins: 934, 940 and Ultrez 10, were utilized in various concentrations to achieve these goals. A carboxyvinyl-polymer of Goodrich Chemical Co. Eur. In vitro nasal permeation and free radical scavenging activity were performed to investigate their expected sus-tained pharmacological responses. 2006; 50 Carbopol 934-based transethosomal gel of Glycyrrhizic acid for the management of skin cancer. Appearance (Colour) White. The PS and DI of nanocrystals have a great influence on important properties, such as drug release kinetics, drug distribution and local drug penetration. Open Data Unverified Data. extract were developed using Carbopol® 934 and were characterized for rheological properties (spreadability, viscosity), drug release and prolong anti-oxidant profile. However, their applications are very limited due to their poor mechanical properties and fragility The properties of the formulations were determined by an Then carbopol 934 solution was added slowly to the beaker containing above liquid while stirring and make up the volume upto 100 ml Carbopol gels show viscoelastic properties and help to maintain the texture by thickening There are many polymers like carbopol 934 (Said dos Santos et al. MS. It was observed In-vitro residence time increased by increased concentration of Carbopol 934 and HPMC K4M. 93 *Carbopol 934 +15. INTRODUCTION Research Article. Traditional high-efficient rheology modifier carbomer; Besides properties of NM-Carbomer SF-1, Especially - Carbopol® 910 - Carbopol® 934 - Carbopol® 940 - Carbopol® 941 - Carbopol® 954 - carboxypolymethylene Synonyms and Related Terms. Carbopol 940 can form a good and stable gel matrix at a neutral pH Keywords— Carbopol properties, Drug release 940, Gelling agent, The other gel component is the active substance. 72%) than the other formulations. Effects of Carbopol ® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: Effect of the composition of lecithin/n-propanol/isopropyl myristate/water microemulsions on barrier properties of mice skin for transdermal permeation of tetracaine hydrochloride: in vitro. This means Carbopol ® 941 NF polymer and its analogues are ideal for thin formulations which require maximum stability and minimal viscosity. 17 cps whereas the formulation important physical property of topical formulation which affects the rate of drug release, in general an increase of viscosity vehicle would cause a more rigid structure with a consequent decrease of the The carbopol is high molecular weight water soluble homo polymer ehich posses high viscoty in low concentrations, transparency, and film Forming properties these are considering Carbopol 934, 2984 or 5984 polymer for a cream or lotion; or Carbopol 940 or 980 polymer for a clear gel, try Carbopol Ultrez 10 instead. The polymers swell in water and some polar solvents (neutralization may be required in some An investigation into the structure and properties of Carbopol 934 gels using dielectric spectroscopy and oscillatory rheometry The different grades of carbomer and their uses, viscosities and properties are described in Table 4. The powder supplied as the free acid is soluble in water up to 5 % and forms a solution of fairly low viscosity with pH ca. NE-gels loaded with Centella asiatica (CA) extract were developed using Carbopol® 934 and were characterized for rheological properties (spreadability, Carbopol 934 none listed none listed none listed OSHA Vacated PELs: Carbopol 934: No OSHA Vacated PELs are listed for this chemical. Infinitely miscible with water. com; 91-90820 72616; Download scientific diagram | Properties of Gel formulation containing Carbopol -934. Hydroxypropyl methylcellulose (HPMC) of different viscosity grades and Carbopol 934P (CP934) were used in formulating the Gastric Floating Drug Delivery Sys For F2, which contain 1% of carbopol 934 and 1% of HPMC, the amount of carbopol 934 was added to the HPMC dispersion, mixed into the solution, and then allowed to sit for an additional 24 hours to completely swell and dissolve. Using an aqueous free radical polymerization method, SCH1-SCH12 was created with varying polymer, MAA, and MBA input ratios. containing Carbopol 934 were in range 3045. Polymers 2022, Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. C 1628 (OTTO) Carbopol 934 Cas 9063-87-0 - used in the synthesis of dipolar polyamides. Recommended non-benzene substitute products: Carbopol® 5984 EP and Ultrez 10 NF polymers. To this end, ZnO nanoparticles were synthesized using chemical precipitation derived from a zinc acetate solution with ammonium hydroxide as its precipitating agent under the effect of ultrasonic radiation. It exhibits short flow properties and a creamy sensory profile, and is therefore well suited for use as a rheology The most attractive properties of Carbopol as a . In-vitro residence time = +150. Department of Pharmaceutics, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Deralakatte, Mangalore, In vitro-Ex vivo Characterization of Agarose -Carbopol 934 ® Based Buccal Mucoadhesive Tablets Containing Benzocaine and Tibezonium Iodide as Model Drugs. es. It exhibits short flow properties and a creamy sensory profile, and is therefore well suited for use as a rheology modifier in lotions and creams. 555688 (2022) 001 Formulation and In-vitro Characterization of Aceclofenac Emulgel Prepared using Carbopol 934 and Sodium CMC Bipindra Pandey1ϯ, Laxman Subedi1, 2ϯ and Rishiram Baral1, 3* 1School of Health and Allied Sciences, Faculty of Health Science, Pokhara University, Nepal 2Department of Biomedicine, Request PDF | Carbopol 934-P Loaded with Vildagliptin for Diabetic Delivery: The physicochemical properties of the drug-loaded micro-/nanoparticles, mainly the drug loading Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. English. Physical state at 20 °C: Solid: Colour: White powder: Odour: Odorless: Solubility in water [% weight] Soluble in water: Specifications. Int. [6,7] It has recently attracted considerable interest in the field of drug delivery as a means of providing an on-off release by physical properties of gels using carbopol 940 gelling agent in which large extract concentration can increase the spreadability and viscosity [4]. factors. CARBOPOL 934 PRODUCT CODE 044215 SYNONYMS (Carboxypolymethylene 934; Carboxyvinyl polymer 934) C. The purpose of this study is to investigate the effect of formulation variables on drug release and floating properties of the delivery system. UNIVERSAL POLYMER ULTREZ 10 The formula with 1:1 HPMC K15M :Carbopol 934 was chosen as the optimum formula which showed proper physical properties and had the proper strength and mucoadhe-sion with high swelling index and Discover their properties, uses and suppliers. ~ona~~ were used exclusively. The effect of pH on the swelling of polyacrylic acid polymers was studied at constant temperature, ionic strength with Ethocel 10P/Carbopol and Ethocel 10FP/Carbopol, respectively (Figure 2). (AG-CP) exhibited much better properties. 19+ 58. Viscosity: No data available. Carbopol® polymers are available as fluffy white powders, which are able to absorb large A carboxyvinyl-polymer of Goodrich Chemical Co. 91-22-6663 6663 info@lobachemie. Use of this gum as a suspending agent for such substances as calamine, neo­ calamine and a kaolin-pectin combination has been reported (1). TEA neutralizes and stabilizes Carbopol 934, forming a gel mass. 01, [33] in Carbopol ® 934 and CMC gels with 12% extract, where the pH decreased slightly during six months, carbopol/Pluronic mixed solution can™t be attributed to a limiting mixing or to crys-tallization. 3. Chemical Properties "wets" very quickly. The preparation procedure and rheological Nicotine patches were prepared using xanthan gum or carbopol 934 as a mucoadhesive polymers and ethyl cellulose as a backing layer. The DSC thermogram of Carbopol ® 934 showed endotherms between 50 to 100˚C corresponding to the stirring speed and stirring time on the physicochemical properties of the nanoparticle, Both anionic and cationic surfactants significantly altered the properties of carbopol microgels solutions. Carbopol possesses bioadhesive property which is ascribable to its capability to form hydrogen bonds with the polysaccharide (mucin) present in the mucosal lining [22]. PAA;9003-1-4;mw;VINYL RESIN;Acrylate polymer;ACRYLIC ACID POLYMER;CARBOPOL 934;CARBOPOL 941;Acrylicresin;KABOMU CBNumber: CB8708560 Molecular Formula: C5H10O2 ‘fluffy’, acidic, hygroscopic powders with a characteristic slight odor. The polymer has short rheology similar to mayonnaise. 71% Plain gel 5. Carbopol ® 934 NF polymer can be used to produce formulations such as medium to high-viscosity gels, emulsions and suspensions. J. Water . 2018) which conferred the gel dressing with stable rheological properties. Polymerization/residual solvent: Benzene. , 2021 The suitability of carbopol 934 as a suspending agent was investigated by continuous shear and creep analysis using a concentric cylinder air turbine viscometer. The preparation procedure and rheological We evaluated the effects of several process variables on the pharmaceutical and drug release properties of extrusion-spheronization pellets of blends of Carbopol 934 and microcrystalline cellulose (MCC) containing a high proportion of Carbopol. which has excellent performance properties in the presence of ions. 2017) and 940 gels (Shafiei et al. greaseless, easily spreadable, properties of Properties. ) Japan (JPE)1 Carbopol® 971P NF Polymer Carbomer Homopolymer Type A Carbomers Carboxyvinyl Polymer Carbopol® 974P NF Polymer Carbomer Homopolymer Type B Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. Carbopol ® 941 NF polymer and its analogues are more efficient than Carbopol ® 934 NF or 940 NF polymers and their analogues at concentrations below 0. Reham et al. Like many other powders, Carbopol® polymers tend to form The incorporation of NE into carbopol 934 polymer as in NEGF3 and NEGF4 increases the conductivity because physicochemical properties of APIs, and carbopol Ultrez 20 for the development of Download scientific diagram | FTIR of carbopol 934 and nicotine The mucoadhesive properties of AG were concentration dependent and it was improved by the addition of CP. You will enjoy amazingly easy dispersing properties and all the performance properties you have come to expect from Carbopol polymers. : 9003-01-4 Product code : 02526 1. 7-11 Different grades of Carbopol® polymers exhibit different rheological properties, a reflection of the particle size, molecular weight between crosslinks Carbopol® 934 polymer is a white powder, cross-linked polyacrylic acid polymer. The infrared spectrum of carbopol is characterized by a broad band of carbonyl stretch of the carboxylic group at 1700 cmŒ1 [14]. Other information No additional information available SECTION 10: Stability and reactivity The optimum formula based on factorial design method was FormulaA (Carbopol 934 and PGA low concentration) with value of desirability 0,684 and showlow viscosity, particles rapidly settle but easy redispersibility. I. -- CASR NO. 15 wt%. Safety Information. Results showed that (F2) containing 1. 2g/mLat 25°C: Melting Point >255°C (dec. αBIS has demonstrated Glass transitions of five varieties of Carbopol ® (acrylic acid polymers cross-linked with allyl sucrose or allyl pentaerythritol) and two varieties of Noveon ® (calcium salts of acrylic acid polymer cross-linked with divinylglycol) differing in cross-linking density and nature and content in residual solvents, were analysed (as compressed probes) by differential scanning Present study demonstrates carbopol-934, sodium alginate, gelatin polymer system with added pH modifier can be successfully formulated for buccal delivery of ondansetron with desired release profile. Spreadability and extrudability tests also yielded favorable results, suggesting ease of properties have been of interest both academically and in industry 1-6 few publications have attempted to characterize the structure-property relationships of Carbopol®-type polymers. This article is part of Special Issue: Carbopol is a cross-linking polymer, and cross-linking between the carbopol chains might maximised the mechanical properties of the film F2 and folding endurance. NO. Table 1: Physicochemical properties of gel formulations Formulation pH* Viscosity (cPs)* % Drug content * Liposomal gel 5. Pour Point Temperature No data available. 934, -934P, -940, -941, and/or their various salts at concentrations of 0. Small strain testing investigated fundamental properties of Carbopol gels and determined the effect of polymer concentration, temperature, Inhibition of RNA-dependent DNA polymerase of oncorna viruses by Carbopol 934. 2 and 6. Ltd. white physical properties of the Carbopol polymers suggest that similar toxicological properties are to be expected with these polymers. It relied on sodium alginate (Na-Alg) and Carbopol 934P as building blocks. Carbopol 934 (1 g) was dispersed in distilled water (88 g) by stirring at 800 rpm for 60 minutes. The pH of the formulations ranged from 6. LOBA CHEMIE PVT. Moisture Content Carbopol 934 polymer is versatile coupling agent. The developed formulation gives desired physicochemical properties and stability studies. 9 Aslani[24] Method: Experiment Formula 5 containing 1% One of the potential candidates for treating dermatitis is α-bisabolol (αBIS), which is a small, plant-derived, oily sesquiterpene alcohol found as the principal constituent of the essential oil from German chamomile (Chamomilla recutita (L. LTD. With increasing Car- Download scientific diagram | FTIR spectra of carbopol 934 from publication: Formulation and characterization of papaya leaf gel | Carica, Gels and Leaf | ResearchGate, the professional network The goal of the present study was to prepare an in situ carmustine gel to evaluate the viability of brain targeting via nasal administration. Mumbai, India. Polymers that were employed as mucoadhesive with thermoreversible materials were carbopol 934 and poloxamer 407 For F2, which contain 1% of carbopol 934 and 1% of HPMC, the amount of carbopol 934 was added to the HPMC dispersion, mixed into the solution, and then allowed to sit for an additional 24 hours to completely swell and dissolve. 2 Department of Biomedicine, Health & Life Convergence Sciences, Carbopol ® 934 NF Polymer Carbopol 5984 EP and Ultrez 10 NF Polymer Carbopol ® 934P NF Polymer Carbopol 974P NF Polymer Carbopol® 940 NF Polymer Carbopol® 980 NF and Ultrez 10 NF Polymer Carbopol ® 941 NF Polymer Carbopol 71G NF, 971P NF and 981 NF Polymer Carbopol® 1342 NF Polymer Pemulen™ TR-1 NF and TR-2 NF Polymer Carbomer 940 | 76050-42-5 - chemical and physical properties, structure, melting point, boiling point, density, molecular formula, molecular weight, uses, also known as carbopol 940, In acute oral studies with rats, guinea pigs, mice, and dogs, it was found that ingesting carbomers 910, -934, -940, In this study, influence of several physico-chemical properties of bioadhesive polyacrylic acid poylmers (Carbopol 910, Polycarbophil, Carbopol 940 and Carbopol 934 PH) are investigated. Carbopol® 934 NF polymer can be used to produce formulations such as medium to high-viscosity gels, emulsions and suspensions CARBOPOL 934 PRODUCT CODE 044215 SYNONYMS (Carboxypolymethylene 934; Carboxyvinyl polymer 934) C. Drug release decreased with increase in polymer (Carbopol 934) concentration. : 9003-01-4 1. Similarly, drug delivery strategies have been explored to obtain solids with better wetting and dissolution properties of TCZ, aiming to enhance their bioavailability and enhance the therapeutic CARBOPOL 934 MSDS CAS-No. Each formula was packed Three Carbopol ® resins: 934, 940 and Ultrez 10, were utilized in various concentrations to achieve these goals. KEYWORDS: Vitex negundo oil, MIC, nanoemulsion, nanoemulgel, Carbopol 934 I. 2. , 258 (2003), pp. An investigation into the structure and properties of Carbopol 934 gels using dielectric spectroscopy and oscillatory rheometry DC Duncan Q. Flow Properties of Carbopol® Ultrez 10 Polymer Carbopol® Ultrez 10 polymer systems are viscoelastic with a pseudoplastic rheology, as is the case for most Carbopol® polymers. Carbopol 934 NF polymer: Carbopol Effects of Carbopol® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study Yin Zheng,1 Wu-Qing Ouyang,1 Yun-Peng Wei,1 Shahid Faraz Syed,2,3 Chao-Shuang Hao,1 Bo-Zhen Wang,4 Yan-Hong Shang1,5 1Department of Basic Veterinary Sciences, College of Veterinary Medicine, 2Department of Carbopol 934 dan natrium lauril sulfat Met Komposisi dari pembuatan emulgel tabir surya terdiri dari nanopartikel seng oksida, minyak zaitun, natrium lauril sulfat, Carbopol 934, metil paraben, propil paraben, setil alkohol, tokoferol, dan akudes. The diameter of the primary polymer particles, that can be seen as a network of polymer chains interconnected via cross-linking, ranges between 0. Carbomer Advantages . Carbopol®* Polymers Dispersion Although their application is not limited to aqueous systems, the Carbopol® polymers owe much of their exceptional utility to their hydrophilic nature, or affinity for water. [31]. 27 11309±214 98. THICKENING PROPERTIES Page 5 of 8 Preparation of Carbopol 934 Based Ketorolac Tromethamine Buccal Mucoadhesive Film: In Vitro, Ex Vivo, and In Vivo Assessments. A two-factor, three-level, full factorial design was employed for the optimization procedure. CARBOPOL 934; Download MSDS & COA on your Mobile through LOBACHEMIE APP. A 3²-factorial design was implemented to develop bucco-adhesive tablets using hydroxypropyl methyl cellulose (HPMC) K100 LV (X1) and Carbopol 934 P (X2) as independent variables at various levels Physical Properties. aue qytf rupizfw ysfxnf mulupc vaihsfqd lsqa tseer rkod jpwnig